12/6/2023 Which physiologic principle will result in an increase in alveolar/alveoli dead space?Read NowAt the same time, multisystem mechanisms regulate systemic acid-base balance in integrative processes that involve gas exchange between tissues and the environment and simultaneous net changes in the concegovntrations of strong and weak ions within, and transfer between, extracellular and intracellular fluids. Gas exchange data does not indicate the presence of right-to-left intrapulmonary shunt developing with exercise, despite recent data suggesting that large-diameter arteriovenous shunt vessels may be recruited with exercise. Inert gas data has shown that the increase in A- aDO 2 is explained by decreased ventilation-perfusion matching, and the development of a diffusion limitation for oxygen. While there is great individual variability, A- aDO 2 is generally largest at peak exercise in subjects with the highest peak oxygen consumption. In healthy subjects, gas exchange, as evaluated by the alveolar-to-arterial PO 2 difference ( A- aDO 2), worsens with incremental exercise, and typically reaches an A- aDO 2 of approximately 25 mmHg at peak exercise. As the first step in the oxygen-transport chain, the lung has a critical task: optimizing the exchange of respiratory gases to maintain delivery of oxygen and the elimination of carbon dioxide.
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